Direct access to functionalized benzotropones, azepanes, and piperidines by reductive cross-coupling of alpha-bromo enones with alpha-bromo enamides

作者:Beng Timothy K*; Sincavage Kayla; Silaire Ann Wens V; Alwali Amir; Bassler Daniel P; Spence Laura E; Beale Oliver
来源:Organic and Biomolecular Chemistry, 2015, 13(19): 5349-5353.
DOI:10.1039/c5ob00517e

摘要

The synthesis of functionalized azepenes and piperidines bearing an alpha-cycloheptenone or benzotropone derivative has been accomplished through direct reductive cross-coupling of alpha-bromo eneformamides or enecarbamates with highly versatile alpha-bromo benzotropone derivatives, under cobalt catalysis. The coupling products have been further elaborated to other synthetically useful aza-heterocyclic frameworks.

  • 出版日期2015