Determinants of age at menarche and time to menstrual cycle regularity in the French E3N cohort

作者：Dossus Laure; Kvaskoff Marina; Bijon Anne; Fervers Beatrice; Boutron Ruault Marie Christine; Mesrine Sylvie; Clavel Chapelon Francoise^*

来源：Annals of Epidemiology, 2012, 22(10): 723-730.

DOI：10.1016/j.annepidem.2012.07.007

• Cohort studies
• Menarche
• Puberty
• Prenatal exposure
• Body size

Purpose: Early menarche has been associated with a greater risk of several major chronic diseases. Although largely genetically determined, age at menarche also has been related to environmental and lifestyle factors.
Methods: Using linear regression models, we explored simultaneously several pre- and postnatal factors as potential determinants of age at menarche and time to menstrual cycle regularity in 96,493 women participating, since 1990, in the French E3N prospective cohort.
Results: Younger age at recruitment, greater father's income index, urban birth place, greater birth length, and larger body silhouette during childhood were associated with an earlier age at menarche (from -1.3 to -4.6 months. P-trend < .0001) whereas greater family size, food deprivation during childhood, and greater birth weight resulted in a delayed menarche (from +1.5 months to +5.3 months, P-trend < .0001). Father's income index, urban birth place, and prematurity predicted a shorter time to menstrual cycle regularity (from -1.1 to -1.9 months, P-trend < .04), whereas birth cohort, larger body silhouette at menarche, and childhood exposure to passive smoking were associated with a longer time to menstrual cycle regularity (from +1.1 months to +8.6 months, P-trend < .006).
Conclusions: Age at menarche and menstrual cycle regularity are significantly influenced by several individual, environmental and lifestyle factors.

• 出版日期2012-10