Adverse obstetric events are associated with significant risk of cerebral palsy

作者：Gilbert William M^*; Jacoby Bryon N; Xing Guibo; Danielsen Beate; Smith Lloyd H

来源：American Journal of Obstetrics and Gynecology, 2010, 203(4): 328.e1.

DOI：10.1016/j.ajog.2010.05.013

• birth asphyxia
• cerebral palsy
• uterine rupture

OBJECTIVE: To examine adverse birth events on the development of cerebral palsy in California.
STUDY DESIGN: A retrospective population-based study of children with cerebral palsy (as of Nov. 30, 2006), matched to their maternal/infant delivery records (Jan. 1, 1991 to Dec. 31, 2001) was performed. Demographic data and intrapartum events were examined. Six adverse birth-related events were chosen. Children without cerebral palsy were controls.
RESULTS: There were 7242 children who had cerebral palsy (59% term) and 31.3% had 1 or more of the 6 adverse intrapartum events (12.9% in controls P < .0001). This held for both term (28.3% vs 12.7% controls) and preterm (36.8% vs 15.9%, controls) neonates (both P < .0001). Maternal (15.1% vs 6.6%) and neonatal (0.9% vs 0.1%) infection were increased in cerebral palsy cases (P < .0001).
CONCLUSION: Almost one-third of children with cerebral palsy had at least 1 adverse birth-related event. Higher rates in the preterm group may partially explain the higher rates of cerebral palsy in this group.

• 出版日期2010-10