Atorvastatin inhibits collar-induced intimal thickening of rat carotid artery: Effect on C-type natriuretic peptide expression

作者：Li, Yongjie; Gao, Yuan; Zeng, Dingyin^*

来源：Molecular Medicine Reports, 2012, 5(3): 675-679.

DOI：10.3892/mmr.2011.698

• atherosclerosis
• pen-arterial collar
• intimal thickening
• atorvastatin
• C-type natriuretic peptide
• cyclic guanosine monophosphate-dependent protein kinase

The present study was performed to elucidate the mechanism underlying the anti-atherogenic action of atorvastatin (ATV). We investigated the effect of ATV on intimal thickening of the rat carotid artery induced by collar placement and further examined the effect of ATV on the expression of C-type natriuretic peptide (CNP), cGMP-dependent protein kinase (PKG) I alpha and PKG I beta in carotid arteries. The expression of CNP was examined by enzyme-linked immunosorbent assay (ELISA) and quantitative real-time RT-PCR. Western blotting was used to determine the expression of PKG I alpha and PKG I beta. After 14 days, the collar placement induced a marked neointima formation and a reduction in CNP and PKG I alpha expression. These effects were significantly reversed by ATV treatment. However, no obvious changes in PKG I beta expression were observed throughout the study. In conclusion, the present data suggest that elevation of CNP represents an additional mechanism by which ATV treatment may prevent the development and progression of atherosclerosis.

• 出版日期2012-3
• 单位中国医科大学