Disease-Related Changes in TRPV1 Expression and Its Implications for Drug Development

作者：Premkumar Louis S^*; Bishnoi Mahendra

来源：Current Topics in Medicinal Chemistry, 2011, 11(17): 2192-2209.

DOI：10.2174/156802611796904834

• TRPV1
• nociceptors
• inflammatory mediators
• pain
• nociceptive ion channels

The transient receptor potential vanilloid 1(TRPV1) channel has been a topic of great interest, since its discovery in 1997. It is a homotetrameric non-selective cation channel predominantly expressed in a population of sensory neurons and its involvement in different modalities of pain has been extensively studied. However, TRPV1 has also been shown to be expressed in non-sensory neurons and non-neuronal cells. TRPV1 is considered as a potential target for drug development, based on its tissue distribution and its role in physiological functions. Here, we summarize the evidences for disease-related alterations in TRPV1 expression and function and review the current perspectives for the therapeutic potential of TRPV1 agonists and antagonists in the treatment of a wide range of diseases.

• 出版日期2011-9