Aminorifannycins and Sporalactams Produced in Culture by a Micromonospora sp Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics

作者：Williams David E; Dalisay Doralyn S; Chen Jessie; Polishchuck Elena A; Patrick Brian O; Narula Gagandeep; Ko Mary; Av Gay Yossef; Li Haoxin; Magarvey Nathan; Andersen Raymond J

来源：Organic Letters, 2017, 19(4): 766-769.

DOI：10.1021/acs.orglett.6b03619

The new ansa macrolide antibiotics 1 to 4 have been isolated from cultures of a Micromonospora sp. obtained from a marine sediment. Rifamycins 1 and 2 are the first natural ansa macrolides to have a 3-amino substituent. Sporalactams A (3) and B (4) are comprised of a heterocylic core 5 and a 14-membered ansa bridge that are both unprecedented. Sporalactam B (4) shows selective and potent inhibition of Mycobacterium tuberculosis.

• 出版日期2017-2-17