High-Yield Method for the Preparation of 1,3,4,5-Tetrahydro-7-methoxy-2H-1-benzazepin-2-one with Excellent Regio- and Stereoselectivity

作者：Piao Feng Yu^*; Xie Yu Zhong; Zhang Wen Bin; Zhang Wei; Han Rong Bi

来源：Synthetic Communications, 2013, 43(14): 1920-1930.

DOI：10.1080/00397911.2012.680571

• Beckmann rearrangement
• ketoxime
• regio- and stereoselectivity

We have surveyed the effects of different acid catalysts, reaction times, and temperatures on the yield, regioselectivity, and stereoselectivity and calculated the ketoxime isomerization and activation energy of the title compound. A facile synthetic procedure with good yields and good regio- and stereoselectivity for Beckmann rearrangement of oxime sulfonate with ZnCl2 in the presence of solvent is developed.

• 出版日期2013-7-18
• 单位延边大学