Abnormal Glucose Tolerance: A Predictor Of 30-Day Mortality In Patients With Decompensate Liver Cirrhosis

作者：Hagel S; Bruns T; Herrmann A; Stallmach A^*; Schmidt C

来源：Zeitschrift für Gastroenterologie, 2011, 49(3): 331-334.

DOI：10.1055/s-0029-1245933

• liver cirrhosis
• mortality
• prognosis
• diabetes mellitus
• impaired glucose tolerance

Background: In liver cirrhosis an abnormal glucose tolerance correlates with a poor long-term prognosis. The aim of this study was to evaluate whether a disturbed glucose metabolism predicts the short-term prognosis in hospitalized patients with decompensated liver cirrhosis.
Methods: Seventy-eight patients with liver cirrhosis were prospectively enrolled. Disturbed glucose metabolism was determined by a 75-g oral glucose tolerance test (OGTT) according to WHO criteria. Differences in survival were assessed by X-2 test for 30-day mortality and by multivariate Cox proportional hazards analysis for long-term survival.
Results: Impaired glucose tolerance (IGT) was diagnosed in 29 patients (37%) and diabetes mellitus (DM) in 26 patients (33%). A pathological OGTT result was a significant negative predictor of a poor 30-day survival compared to NGT (OR 8.6; p = 0.03). DM but not IGT was an independent negative predictor of long-term survival (HR = 1.89; p = 0.04).
Conclusion: Disturbed glucose metabolism in hospitalized patients with decompensated liver cirrhosis is correlated with increased 30-day mortality. OGTT appears to be useful for identifying cirrhotic patients with poor short term prognosis.

• 出版日期2011-3