An enantioselective organocatalyzed aza-MBH domino process: application to the facile synthesis of tetrahydropyridines

作者：Takizawa Shinobu; Inoue Naohito; Sasai Hiroaki^*

来源：Tetrahedron Letters, 2011, 52(3): 377-380.

DOI：10.1016/j.tetlet.2010.11.045

• Acid base organocatalyst
• Domino reaction
• Aza-MBH reaction
• Tetrahydropyridines
• Enantioselective reaction

A chiral acid-base organocatalyst was found to promote an aza-MBH domino process between alpha,beta-unsaturated carbonyl compounds and N-tosylimines to afford tetrahydropyridine derivatives with high enantioselectivity.

• 出版日期2011-1-19