Affective reactivity in heroin-dependent patients with antisocial personality disorder

作者：Walter Marc^*; Degen Bigna; Treugut Constanze; Albrich Juergen; Oppel Monika; Schulz Andre; Schaechinger Hartmut; Duersteler MacFarland Kenneth M; Wie**eck Gerhard A

来源：Psychiatry Research, 2011, 187(1-2): 210-213.

DOI：10.1016/j.psychres.2010.10.017

• Addiction
• Antisocial personality disorder
• Heroin
• Opioid maintenance treatment
• Startle reflex

The Antisocial personality disorder (ASPD), one of the most common co-morbid psychiatric disorders in heroin-dependent patients, is associated with a lack of affective modulation. The present study aimed to compare the affect-modulated startle responses of opioid-maintained heroin-dependent patients with and without ASPD relative to those of healthy controls. Sixty participants (20 heroin-dependent patients with ASPD, 20 heroin-dependent patients without ASPD, 20 healthy controls) were investigated in an affect-modulated startle experiment. Participants viewed neutral, pleasant, unpleasant, and drug-related stimuli while eye-blink responses to randomly delivered startling noises were recorded continuously. Both groups of heroin-dependent patients exhibited significantly smaller startle responses (raw values) than healthy controls. However, they showed a normal affective modulation: higher startle responses to unpleasant, lower startle responses to pleasant stimuli and no difference to drug-related stimuli compared to neutral stimuli. These findings indicate a normally modulated affective reactivity in heroin-dependent patients with ASPD.

• 出版日期2011-5-15