A novel Enterovirus 96 circulating in China causes hand, foot, and mouth disease

作者：Xu, Yi; Sun, Yisuo; Ma, Jinmin; Zhou, Shuru; Fang, Wei; Ye, Jiawei; Tan, Limei; Ji, Jingkai; Luo, Dan; Li, Liqiang; Li, Jiandong; Fang, Chunxiao; Pei, Na; Shi, Shuo; Liu, Xin; Jiang, Hui; Gong, Sitang^*; Xu, Xun^*

来源：Virus Genes, 2017, 53(3): 352-356.

DOI：10.1007/s11262-017-1431-5

• Enterovirus 96
• Metagenomics
• HFMD
• Genome sequence
• Evolution

Enterovirus 96 (EV-96) is a recently described member of the species Enterovirus C and is associated with paralysis and myelitis. In this study, using metagenomic sequencing, we identified a new enterovirus 96 strain (EV-96-SZ/GD/CHN/2014) as the sole pathogen causing hand, foot, and mouth disease (HFMD). A genomic comparison showed that EV-96-SZ/GD/CHN/2014 is most similar to the EV-96-05517 strain (85% identity), which has also been detected in Guangdong Province. This is the first time that metagenomic sequencing has been used to identify an EV-96 strain shown to be associated with HFMD.

• 出版日期2017-6
• 单位深圳华大生命科学研究院; 广州市妇女儿童医疗中心