Adherence, persistence and switch rates for anticholinergic drugs used for overactive bladder in women: data from the Norwegian Prescription Database

作者：Mauseth Siri A; Skurtveit Svetlana; Spigset Olav^*

来源：Acta Obstetricia et Gynecologica Scandinavica, 2013, 92(10): 1208-1215.

DOI：10.1111/aogs.12196

• Adherence
• anticholinergic drugs
• epidemiology
• overactive bladder
• persistence

ObjectiveTo investigate the pattern of use of anticholinergic drugs for overactive bladder among women in Norway with regard to persistence, adherence and switch rates. %26lt;br%26gt;DesignObservational study. %26lt;br%26gt;Setting and sampleData from the Norwegian Prescription Database on prescriptions for tolterodine, solifenacin, darifenacin and fesoterodine filled in Norwegian pharmacies from 1 January 2004 to 31 December 2010. %26lt;br%26gt;Methods and main outcome measuresData from the database were analysed at an individual level, and drug persistence, discontinuation rates and switch rates during a follow-up period of 365days after the first prescription were calculated. %26lt;br%26gt;ResultsOverall 1-year persistence for new users was 38.0%. Within the same period, a total of 10.3% switched from the index drug to another drug in the same group, whereas 51.7% discontinued without switching. Users of solifenacin and tolterodine were somewhat more persistent than users of darifenacin and fesoterodine. Persistence was lowest (20.9%) in the age group 18-39years, increased with age and was highest in the age groups 70-79years and 80years and above (43.5 and 43.3%, respectively). In total, 31.9% filled only one prescription of the drug and, of these, only one of four women switched to another drug. The proportion who were adherent during treatment was 60.4%. %26lt;br%26gt;ConclusionsThe discontinuation rate for anticholinergic drugs for overactive bladder in women is high. The reasons why patients stop using them remain obscure but could be related both to a limited clinical effect and an unacceptable adverse effect burden.

• 出版日期2013-10