A Rocket-Like Encapsulation and Delivery System with Two-Stage Booster Layers: pH-Responsive Poly(methacrylic acid)/Poly(ethylene glycol) Complex-Coated Hollow Silica Vesicles

作者：Lay Chee Leng; Kumar Jatin N; Liu Connie K; Lu Xuehong; Liu Ye^*

来源：Macromolecular Rapid Communications, 2013, 34(19): 1563-1568.

DOI：10.1002/marc.201300529

• hydrogen bonds
• polyethers
• silicas
• stimuli-sensitive polymers
• vesicles

Rocket-like vesicles formed are composed of poly(acrylic aicd) (PMAA )/poly(ethylene glycol) (PEG) complex coated hollow silica spheres, and the structure and composition of the vesicles are characterized using TGA, 1H NMR, FTIR, and TEM. Although only one-third of EG units of PEG brushes grafted to hollow silica spheres form the complex with PMAA via hydrogen bonding, the first booster layer composed of PMAA/PEG complex can provide secure encapsulation of model compound calcein blue under an acidic condition. The second booster layer composed of PEG brushes can be formed by changing acidic pH to 7.4 through the disassociation of the PMAA/PEG complex. A higher molecular weight PMAA exhibits a faster disassembly due to the formation of a looser PMAA/PEG complex on the surfaces of hollow silica spheres.

• 出版日期2013-10
• 单位南阳理工学院