Definitive proton radiation therapy and concurrent cisplatin for unresectable head and neck adenoid cystic carcinoma: A series of 9 cases and a critical review of the literature

作者：Bhattasali Onita; Holliday Emma; Kies Merrill S; Hanna Ehab Y; Garden Adam S; Rosenthal David I; Morrison William H; Gunn G Brandon; Fuller C David; Zhu X Ronald; Frank Steven J^*

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2016, 38(S1): E1472-E1480.

DOI：10.1002/hed.24262

• proton radiotherapy
• chemotherapy
• adenoid cystic
• head and neck neoplasms

Background. The primary treatment for head and neck adenoid cystic carcinoma (ACC) is surgery. Infrequently, however, ACC's propensity for perineural and base of skull invasion can preclude definitive surgical management. We present our experience with proton radiation therapy (RT) and concurrent platinum-based chemotherapy.
Methods. Nine patients with unresectable node-negative, nonmetastatic head and neck ACC received definitive proton RT and concurrent cisplatin. Outcomes and toxicities were recorded. A systematic review of the literature was performed.
Results. Median follow-up was 27 months (range, 9.2-48.3 months). Four patients achieved complete response at the primary site, and an additional 4 patients achieved stabilization of local disease. Only 1 patient developed local disease progression. Four patients had 5 acute grade 3 (G3) toxicities, and 1 patient developed a chronic G4 optic nerve disorder.
Conclusion. Our preliminary results suggest proton RT and concurrent chemotherapy is a definitive treatment option for select patients with head and neck ACC.

• 出版日期2016-4