Detection and credibility of sentinel node in vulvar cancer: a single institutional study and short review of literature

作者：Akrivos Nikolaos^*; Rodolakis Alexandros; Vlachos George; Sotiropoulou Maria; Papantoniou Vasileios; Biliatis Ioannis; Haidopoulos Dimitrios; Thomakos Nikolaos; Simou Maria; Antsaklis Aris

来源：Archives of Gynecology and Obstetrics, 2011, 284(6): 1551-1556.

DOI：10.1007/s00404-011-1884-z

• Sentinel node
• Vulvar cancer
• Blue dye
• Technetium

Purpose To evaluate the detectability and credibility of sentinel lymph node (SLN) in vulvar cancer.
Methods With Tc99m-nanocolloid and methylene blue, we identified SLNs in 34 patients. In 27 cases both tracers were used, while in 7 only blue dye was used. Completion lymphadenectomy was performed in all patients. SLNs and non-SLNs were sent separately for pathologic evaluation.
Results At least one SLN was identified in all patients. Detection rate per groin was not significantly higher in the combined versus blue dye only technique (42/50 vs. 10/14, p = 0.43). 99m-Tc was not superior to blue dye in detecting SLN (42/50 vs. 50/64, p = 0.65). Midline location of the tumor did not seem to negatively affect the procedure. Four false negatives were observed in three patients with tumors > 4 cm. Negative predictive value of SLN was 100% for grade I tumors a parts per thousand currency sign4 cm in patients a parts per thousand currency sign71 years.
Conclusion Tc-99m does not seem to be superior to methylene blue in the detection of SLN in vulvar cancer. Patients of younger age with small, well-differentiated tumors appear to be the most suitable candidates for lymphatic mapping.

• 出版日期2011-12