Size-tunable protein-polymer hybrid carrier for cell internalization

作者：Lee Chaeyeon; Choi Ji Eun; Park Gil Yong; Lee Taeheon; Kim Jinku; An Seong Soo A; Song Jae Kwang^*; Paik Hyun jong^*

来源：Reactive and Functional Polymers, 2018, 124: 72-76.

DOI：10.1016/j.reactfunctpolym.2018.01.006

• Polymer-protein core-shell particle
• Functional nanocarrier
• One-pot method
• Size-control
• Endocytosis

We describe a polymer-templated protein nanoball (PTPNB) system as an in-situ platform for the preparation of polymer-protein core-shell capsules containing hydrophobic cargos. These structures boast high protein activity through soft immobilization and maintain a consistent protein orientation through a specific interaction between the protein and polymer. We demonstrate the potential of this PTPNB system through bio-conjugation, encapsulation, and size-control of nanoballs in a one-pot process, and furthermore characterize the effects of nanoball size on endocytosis.

• 出版日期2018-3