N-sulfonylbenzotriazoles as advantageous reagents for C-sulfonylation

作者：Katritzky AR^*; Abdel Fattah AAA; Vakulenko **; Tao H

来源：Journal of Organic Chemistry, 2005, 70(23): 9191-9197.

DOI：10.1021/jo051157i

Reactions of readily available N-(alkyl-, aryl-, and heteroarylsulfonyl)benzotriazoles 3a-h with diverse nitriles, reactive heteroaromatics, alkylheteroaromatics, sulfones, and esters produced alpha-cyanoalkyl sulfones 5a-i, sulfonylheteroaromatics 7a-e, alpha-(sulfonylalkyl)heterocycles 9a-f, alpha-sulfonylalkyl sulfones 11a-g, and esters of alpha-sulfonyl acids 14a-c, respectively, in synthetically useful to excellent yields. The results represent the first examples of the successful application of sulfonylazoles for C-sulfonylation.

• 出版日期2005-11-11