Alpha-1 Antitrypsin Levels and Polymorphisms in Interstitial Lung Diseases

作者：Demir Nalan; Ercen Diken Ozlem; Karabulut Halil Gurhan; Karnak Demet; Kayacan Oya

来源：Turkish Journal of Medical Sciences, 2017, 47(2): 476-482.

DOI：10.3906/sag-1508-76

• Alpha-1 antitrypsin deficiency
• idiopathic interstitial pneumonias
• interstitial lung disease

Background/aim: Alpha-1 antitrypsin deficiency may be a potential predisposing factor for interstitial lung fibrosis. We investigated alpha-1 antitrypsin levels and its polymorphisms in patients with interstitial lung disease.
Materials and methods: A total of 103 interstitial lung disease patients were compared.
Results: The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 perpendicular to 0.33 g/L, and it was 1.54 perpendicular to 0.37 g/L in patients with nonidiopathic interstitial pneumonia (P = 0.13). Low alpha-1 antitrypsin levels were more frequently observed in nonidiopathic interstitial pneumonia patients compared with idiopathic interstitial pneumonia, but the difference was not statistically significant (8.9% vs. 0%, respectively, P = 0.4). In 100 patients, the normal PiMM genotype was detected, while abnormal ones (PiMZ, n = 2, 1.9%; PiMS, n = 1, 0.97%) were determined in three cases. When the frequency of alpha-1 antitrypsin polymorphism in interstitial lung disease patients was compared with the data of the healthy population, no significant difference was detected for the PiMZ and PiMS variants (P = 0.15 and P = 0.44, respectively).
Conclusion: Lower levels of serum alpha-1 antitrypsin were more frequent in nonidiopathic interstitial pneumonia patients than idiopathic interstitial pneumonia without an increase in genetic polymorphism. The difference was not statistically significant.

• 出版日期2017