科研之友
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摘要
Estrogen receptor alpha (ESR alpha) gene expresses in prostate stromal cells and may associate with prostate cancer risk, while the relationship between ESR alpha polymorphisms and therapeutic outcome as well as prognosis of patients with prostate cancer in Chinese Han population has not been clarified. Genotypes of rs2234693 and rs9340799 in ESR alpha gene were detected in 168 ADT-resistant patients with prostate cancer and 220 healthy controls by PCR-RFLP. The associations of these polymorphisms with the risk, object response rate (ORR), disease control rate (DCR) and progression free survival (PFS) of prostate cancer were analyzed by chi-square test, Kaplan-Meier method and log-rank test. The distributions of rs2234693 and rs9340799 genotypes in patients and controls were significantly difference (all P<0.05). ORR was significantly higher in TT genotype of rs2234693 (X-2=7.288, P=0.026) or GG genotype of rs9340799 (X-2=9.118, P=0.010) carriers. DCR was no significantly difference among each genotypes (rs2234693: X-2=4.541, P=0.103; rs9340799: X-2=5.063, P=0.080). Median PFS (mPFS) in T-allele of rs2234693 carriers were 1.33 folds higher than CC carriers (Log rank P<0.05), while mPFS in combined cohort of GA+AA of rs9340799 was 2 folds higher than GG carriers (Log rank P<0.05). Stratified by Gleason score, the mPFS in CT and the combined cohort of CT+TT of rs2234693 carriers were 1.5 folders higher than that in CC (Log rank P<0.05) carried patients with lower (<= 6) Gleason score. The polymorphisms rs2234693 and rs9340799 in ESR alpha gene were associated with the therapeutic outcome and short-term prognosis of patients with ADT-resistant prostate cancer in Chinese Han population, and could be considered a valuable biomarker for survival.
- 出版日期2016
- 单位新乡医学院
