A concise synthesis of 4 '-O-methyl honokiol

作者：Denton Ross M^*; Scragg James T; Saska Jan

来源：Tetrahedron Letters, 2011, 52(20): 2554-2556.

DOI：10.1016/j.tetlet.2011.03.031

• 4 '-O-Methyl honokiol
• Natural products
• Dienone addition/rearrangement
• Neolignans

A concise and protecting group free synthesis of the naturally occurring neolignan 4'-O-methyl honokiol is developed. The key biaryl bond is constructed by 1,2-addition of an aryl Grignard reagent to a dienone followed by rearrangement.

• 出版日期2011-5-18