Mapping the surface charge distribution of amyloid fibril

作者：Lee Gyudo; Lee Wonseok; Lee Hyungbeen; Lee Sang Woo; Yoon Dae Sung; Eom Kilho; Kwon Taeyun^*

来源：Applied Physics Letters, 2012, 101(4): 043703.

DOI：10.1063/1.4739494

It is of high importance to measure and map the surface charge distribution of amyloids, since electrostatic interaction between amyloidogenic proteins and biomolecules plays a vital role in amyloidogenesis. In this work, we have measured and mapped the surface charge distributions of amyloids (i.e., beta-lactoglobulin fibril) using Kelvin probe force microscopy. It is shown that the surface charge distribution is highly dependent on the conformation of amyloids (e.g., the helical pitch of amyloid fibrils) as well as the pH of a solvent. VC 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4739494]

• 出版日期2012-7-23