Toll-like receptor signalling and their therapeutic targeting in colorectal cancer

作者：Moossavi Shirin; Rezaei Nima^*

来源：International Immunopharmacology, 2013, 16(2): 199-209.

DOI：10.1016/j.intimp.2013.03.017

• Colorectal cancer
• Toll-like receptors
• Susceptibility
• Tumorigenesis
• Treatment
• Prognosis

Intestinal homeostasis is dependent on the proper host/microbiota interaction via pattern recognition receptors. Toll-like receptors are a specialised group of membrane receptors which detect pathogen-associated conserved structures. They are present in the intestinal tract and are required for intestinal homeostasis. Dysregulation in the Toll-like receptor signalling can conceivably result in a dysregulated immune response which could contribute to major intestinal pathologies including colorectal cancer. Evidence for the role of microbiota and toll-like receptors in colorectal cancer is emerging. In this report the evidence for the contribution of toll-like receptors to the pathogenesis of colorectal cancer; potential mechanisms affecting toll-like receptor signalling; and their therapeutic targeting in colorectal cancer are reviewed.

• 出版日期2013-6