A STRUCTURED MODEL FOR THE SPREAD OF MYCOBACTERIUM MARINUM: FOUNDATIONS FOR A NUMERICAL APPROXIMATION SCHEME

作者：Ackleh Azmy S^*; Delcambre Mark L; Sutton Karyn L; Ennis Don G

来源：Mathematical Biosciences and Engineering, 2014, 11(4): 679-721.

DOI：10.3934/mbe.2014.11.679

• Structured models
• finite difference approximation
• existence-uniqueness
• convergence
• mycobacterial infections
• behavior of solutions

We develop a finite difference scheme to approximate the solution of a novel size-structured mathematical model of the transmission dynamics of Mycobacterium marinum (Mm) in an aquatic environment. The model consists of a system of nonlinear hyperbolic partial differential equations coupled with three nonlinear ordinary differential equations. Existence and uniqueness results are established and convergence of the finite difference approximation to the unique bounded variation weak solution of the model is obtained. Numerical simulations demonstrating the accuracy of the method are presented. We also conducted preliminary studies on the key features of this model, such as various forms of growth rates (indicative of possible theories of development), and conditions for competitive exclusion or coexistence as determined by reproductive fitness and genetic spread in the population.

• 出版日期2014-8