Novel Stealth Nanoparticles Prepared by Dispersion Polymerization Novel stealth degradable nanoparticles prepared by dispersion polymerization for the delivery of bioactive agents Part I

作者：Akala Emmanuel Oyekanmi^*; Okunola Oluyomi

来源：Pharmazeutische Industrie, 2013, 75(7): 1191-+.

• Controlled drug release
• Dispersion polymerization
• Nanoparticles
• Paclitaxel
• Redox initiator

Purpose: Finding effective treatments for life-threatening diseases such as cancer is one of the challenges facing biomedical research. Integration of the promises of nanotechnology with cancer research can provide enduring solutions to the challenges. The uniqueness of polymeric nanoparticles makes them suitable for this application: stability, maneuverability, surface nanoengineering, controlled drug release and tumor targeting. Methods: Two types of initiator were used for the preparation of stealth degradable nanoparticles by free radical dispersion polymerization. A 4(2) factorial experimental design was carried out by varying crosslinker concentration and the concentration of methyl methacrylate. The amounts of poly(ethylene glycol)n monomethyl ether mono methacrylate (PEG-MA) macromonomer and the initiator were kept constant. Results and discussion: The nanoparticles were characterized for surface morphology and structure, particle size, loading efficiency and drug release. Analysis of variance shows that the two factors are significant; the interaction is also significant. Numerical optimization (particle size minimization) was carried out. In vitro availability isotherms of paclitaxel- and 2-chloro-3-diacetylamino-1,4-naphthoquinone (Zapp88)-loaded nanoparticles indicate that the release of the two drugs was sustained for 19 to 37 days. Conclusion: The nanoparticles are suitable for the development of controlled drug delivery devices.

• 出版日期2013