Flavonoids from Caragana pruinosa roots

作者：Peng, Wei; Wang, Liang; Qiu, Xu-Hui; Jiang, Yi-Ping; Pan, Lan; Jia, Xiao-Guang; Qin, Lu-Ping^*; Zheng, Cheng-Jian^*

来源：Fitoterapia, 2016, 114: 105-109.

DOI：10.1016/j.fitote.2016.08.020

• Caragana pruinosa
• Flavonoids
• Pruinosanones
• Nitric oxide

A new pterocarpan derivative, pruinosanone D (1), a new isoflavonoid, pruinosanone E (2), and a new chalcone, pruinosanone F (3), were isolated from Caragana pruinosa roots, along with four known analogues (4-7), identified as 2,4-dihydroxy-3'-methoxy-4'-ethoxychalcone, 7,4-dihydroxyflavanone, butin and scutellaprostin C, respectively. Their structures were elucidated by detailed analyses of NMR, IR, and MS data. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages was also studied. Compound 1 were among the most potent NO production inhibitor, with IC50 value of 0.62 mu M.

• 出版日期2016-10
• 单位新疆维吾尔自治区中药民族药研究所; 成都中医药大学; 中国人民解放军第二军医大学