A convenient methodology for the chemoselective reduction of a wide variety of functionalized alkenes

作者：Babler James H^*; White Nicholas A

来源：Tetrahedron Letters, 2010, 51(2): 439-441.

DOI：10.1016/j.tetlet.2009.11.061

An efficient method to effect chemoselective reduction of alkenes (including trisubstituted olefins) possessing various sensitive and/or reducible groups Such as acetals, allylic alcohols, benzyl ethers, epoxides, esters, halides, nitriles, and sulfones is reported. The reduction is facile at 0 degrees C in aqueous N,N-dimethylacetamide containing sodium borohydride in the presence of 15 mol % ruthenium(III) chloride. Regioselective reduction of dienes is also feasible if the double bonds are sufficiently different in their structural environment.

• 出版日期2010-1-13