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摘要
Both angiotensin-converting enzyme (ACE) and serotonin (5-HT) are known to be implicated in the pathogenesis of migraine, but data on the association between polymorphisms in the ACE gene and serotonin transporter (5-HTT) are inconsistent. The objective of this meta-analysis was to investigate the association between the ACE I/D and the 5-HTT STin variable-number tandem repeat (VNTR) polymorphisms and migraine. Relevant studies were identified using the PubMed and EMBASE databases. We used odds ratios (ORs) with 95% confidence intervals (CIs) to evaluate the effect of the ACE I/D and 5-HTT STin VNTR polymorphisms on migraine in a random-effects or fixed-effects model. We also performed subgroup analyses by ethnicity and migraine status. Nineteen studies were included in this meta-analysis (twelve on the ACE I/D polymorphism and seven on the 5-HTT ST in VNTR polymorphism). The overall results indicated a statistically significant association between the ACE I/D polymorphism and increased susceptibility to migraine with aura (MA) in heterozygote models (DI vs. II: OR = 1.16, 95% CI = 1.02-1.31), P = 0.02; I-2 = 17%) and dominant models (DD + DI vs. II: OR = 1.14, 95% CI = 1.02-1.28, P = 0.02; I-2 = 44%) and without aura (MO) in homozygote models (DD vs. II: OR = 1.13, 95% CI = 1.01-1.27, P = 0.03; I-2 = 11%), heterozygote models (DI vs. II: OR = 1.13, 95% CI = 1.02- 1.24, P = 0.02; I-2 = 10%), and dominant models ( DD + DI vs. II: OR = 1.12, 95% CI = 1.02-1.23, P = 0.02; I-2 = 17%). Subgroup analyses revealed that there is no increased migraine susceptibility observed among Asians. The STin2.12/12 genotype significantly increased the risk of developing MO (OR = 1.31, 95% CI = 1.03-1.66, P = 0.03; I-2 = 31%). Thus, this meta-analysis demonstrates that the ACE D-carrier genotypes are associated with increased risk of migraine with and without aura, although not among Asian populations. The 5-HTT STin2.12/12 genotype is a risk factor for MO.
- 出版日期2017
- 单位南京医科大学
