A facile one-step synthesis of 5-chloro-imidazo[1,5-a]quinazoline by microwave irradiation

作者：Li Guo^*; Kakarla Ramesh; Gerritz Samuel W; Pendri Annapurna; Ma Baoqing

来源：Tetrahedron Letters, 2009, 50(44): 6048-6052.

DOI：10.1016/j.tetlet.2009.08.054

• Imidazoquinazoline
• 4-Quinazolinone
• Microwave

A new and facile method has been developed for the one-step synthesis of 5-chloro-imidazol[1,5-a]quinazoline by cyclization of N-acylanthranilic acid A with 2-amino acetamide B1 or 2-amino-acetonitrile B2 in the presence of POCl(3) under microwave irradiation. 5-chloro-imidazo[1,5-a]quinazolines can be further functionalized by displacement of 5-Cl group.

• 出版日期2009-11-4