A Dynamical Modeling to Study the Adaptive Immune System and the Influence of Antibodies in the Immune Memory

作者：de Castro Alexandre^*; Fronza Carlos Frederico; Alves Domingos

来源：Computer Modeling in Engineering & Sciences, 2009, 45(1): 83-96.

• immune memory
• antibodies
• B-cells

Immunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to chall enging problems of modem computing. Simulation systems and mathematical modeling are also beginning use to answer more complex immunological questions as immune memory process and duration of vaccines, where the regulation mechanisms are not still known sufficiently (Lundegaard, Lund, Kesmir, Brunak, Nielsen, 2007). In this article we studied in machina a approach to simulate the process of antigenic mutation and its implications for the process of memory. Our results have suggested that the durability of the immune memory is affected by the process of antigenic mutation.and by populations of soluble antibodies in the blood. The results also strongly suggest that the decrease of the production of antibodies favors the global maintenance of immune memory.

• 出版日期2009-5