Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture

作者：Hirayama Tasuku; Taki Masayasu^*; Akaoka Kazushi; Yamamoto Yukio

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(24): 7410-7413.

DOI：10.1016/j.bmcl.2012.10.061

• Ratiometric fluorescent sensor
• Time-resolved detection
• Zn2+ peptidyl chemosensor
• Energy transfer
• Lanthanide complex

A synthetic peptide bearing a lanthanide complex, TbOTZ exhibits a decrease of chromophore fluorescence and a concomitant luminescence enhancement due to sensitized Tb3+ upon Zn2+ binding. Thus, TbOTZ can be a valuable tool for ratiometric sensing of Zn2+ as well as for time-resolved fluorescence detection with a single molecule.

• 出版日期2012-12-15