NW-G01, a novel cyclic hexadepsipeptide antibiotic, produced by Streptomyces alboflavus 313: I. Taxonomy, fermentation, isolation, physicochemical properties and antibacterial activities

作者：Guo Zhengyan; Shen Ling; Ji Zhiqin; Zhang Jiwen; Huang Luzhi; Wu Wenjun^*

来源：Journal of Antibiotics, 2009, 62(4): 201-205.

DOI：10.1038/ja.2009.15

• antibacterial activity
• cyclic hexadepsipeptide
• NW-G01
• Streptomyces alboflavus 313

NW-G01, a novel cyclic hexadepsipeptide antibiotic, was isolated by macroporous resin and silica gel column chromatography and HPLC from the fermentation broth of strain no. 313. The producing strain was identified as Streptomyces alboflavus on the basis of the morphological characteristics, physiological property and 16S rDNA gene sequence analysis. NW-G01 exhibited strong antibacterial activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, methicillin-resistant S. aureus, and their MIC values were 3.90, 3.90, 7.81 and 7.81 mu g ml(-1), respectively. The Journal of Antibiotics (2009) 62, 201-205; doi:10.1038/ja.2009.15; published online 6 March 2009

• 出版日期2009-4
• 单位西北农林科技大学