Apoptosis, Up the Ante

作者:Thandapani Palaniraja; Aifantis Iannis*
来源:Cancer Cell, 2017, 32(4): 402-403.
DOI:10.1016/j.ccell.2017.09.009

摘要

The clinical success of the BH3-mimetic venetoclax has generated increasing interest to target BCL2 family proteins in oncology. In this issue of Cancer Cell, Reyna and colleagues demonstrate the potential of a pharmacological activator of the pro-apoptotic protein BAX to suppress acute myeloid leukemia both alone and together with venetoclax.

  • 出版日期2017-10-9