ALLERGIC AND PSEUDOALLERGIC DRUG REACTIONS

作者：Turkalj Mirjana^*

来源：Paediatria Croatica, 2012, 56: 112-120.

• DRUG ALLERGY
• PSEUDOALLERGIC DRUG REACTION
• IGE MEDIATED REACTION
• NON-IGE MEDIATED REACTION

A drug allergy, or an allergic drug reaction, is an adverse drug reaction that results from a specific immunologic response to a medication. The World Allergy Organization (WAO) has recommended dividing immunologic drug reactions into immediate reactions or IgE-mediated and delayed reactions or not IgE-mediated (onset after one hour), based upon the timing of the appearance of symptoms. Immunologic drug reactions may be divided into four categories according to the Gell and Coombs system: type I. mediated by IgE and mast cells/basophils, type II: caused by antibody (usually IgG) mediated cell destruction, type III: caused by IgG and drug immune complex deposition and complement activation, and type IV: T cell-mediated. Type IV reactions are further subdivided into types IVa, IVb, IVc, and IVd, depending upon the other cell types involved. Pseudoalleigic drug reactions are adverse drug reactions with signs and symptoms that mimic immunologic drug allergies, but in which immunologic mechanism have not be demonstrated. Pseudoallergic reactions are especially difficult to distinguish clinically because they can be similar or identical in presentation to true allergic reactions.

• 出版日期2012