Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol

作者：Li, Xu Qin; Yang, Yun Xu^*; Wang, Wei Li; Hu, Bin; Xue, Hui Min; Zhang, Tian Yi; Zhang, Xue Tao

来源：Chinese Chemical Letters, 2011, 22(7): 765-767.

DOI：10.1016/j.cclet.2011.01.007

• L-Carnitine
• Cyclic sulfite
• (R)-3-Chloro-1,2-propanediol

A practical chemical synthesis of L-carnitine (1) has been accomplished from (R)-3-chloro-1,2-propanediol ((R)-4), which is a main by-product originated from (R,R)-Salen Co(III) catalyzed hydrolytic kinetic resolution (HKR) of (+/-)-epichlorohydrin. (R)-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite ((R)-5). The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.

• 出版日期2011-7
• 单位北京科技大学