Photo-protective activity of pogostone against UV-induced skin premature aging in mice

作者：Wang, Xiu Fen; Huang, Yan Feng; Wang, Lan; Xu, Lie Qiang; Yu, Xiu Ting; Liu, Yu Hong; Li, Cai Lan; Zhan, Janis Ya Xian; Su, Zi Ren; Chen, Jian Nan^*; Zeng, Hui Fang^*

来源：Experimental Gerontology, 2016, 77: 76-86.

DOI：10.1016/j.exger.2016.02.017

• Pogostone
• Photoaging
• Ultraviolet
• Antioxidant
• Anti-inflammation
• Matrix metalloproteinases

Pogostone, a chemical constituent of patchouli oil, has been confirmed to possess favorable anti-inflammatory property. In the present study, we investigated the possible anti-photoaging potential of pogostone and the underlying mechanism against UV-induced skin damage in mice. The macroscopic and histopathological lesions were significantly ameliorated by pretreatment of pogostone as compared to the VC group. Furthermore, topical application of pogostone markedly increased the activities of the antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and observably decreased malonaldehyde (MDA) level. Analysis of inflammatory cytokines showed obvious down-regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and cyclooxygenase-2 (COX-2), prostaglandin E-2 (PGE2) in the pogostone groups. In addition, pogostone pretreatment evidently inhibited the abnormal expression of matrix metalloproteinases (MMP-1 and MMP-3). Taken together, pogostone exhibited prominent photo-protective activity mainly by its antioxidative and anti-inflammatory properties, promising it as an effective alternative pharmaceutical therapy for photoaging.

• 出版日期2016-5
• 单位广州中医药大学