ASSIGNMENT OF THE DIPEPTIDYLPEPTIDASE-IV (DPP4) GENE TO PIG CHROMOSOME-15Q21

作者：THOMSEN PD^*; QVIST H; MARKLUND L; ANDERSSON L; SJOSTROM H; NOREN O

来源：Mammalian Genome, 1993, 4(10): 604-607.

DOI：10.1007/BF00361393

A porcine 2-kb partial dipeptidylpeptidase IV (DPP4, EC 3.4.14.5) cDNA clone and a porcine 16-kb genomic fragment containing parts of the DPP4 gene were isolated, characterized, and used as probes to map the DPP4 gene to pig Chr (Chr) 15q21 by fluorescence in situ hybridization. A two-allele RFLP was revealed for the DPP4 gene. This polymorphism was utilized in a linkage test against the erythrocyte antigen G (EAG), previously assigned to Chr 15, and the microsatellite S0088, which is linked to EAG. The linkage analyses revealed significant evidence for linkage confirming the assignment of DPP4 to Chr 15.

• 出版日期1993