NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson%26apos;s disease

作者：Martinez Fong Daniel^*; Bannon Michael J; Trudeau Louis Eric; Gonzalez Barrios Juan A; Arango Rodriguez Martha L; Hernandez Chan Nancy G; Reyes Corona David; Armendariz Borunda Juan; Navarro Quiroga Ivan

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2012, 8(7): 1052-1069.

DOI：10.1016/j.nano.2012.02.009

• Neurorestoration
• Neuroprotection
• Neurodegeneration
• Regeneration
• Survival

Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson%26apos;s disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a %26quot;Trojan horse%26quot; synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson%26apos;s disease. %26lt;br%26gt;From the Clinical Editor: This review paper focuses on nanomedicine-based treatment of Parkinson%26apos;s disease, a neurodegenerative condition with existing symptomatic but no curative treatment. Neurotensin-polyplex is a synthetic nanocarrier system that enables delivery of genetic cargo to dopaminergic neurons via NTS receptor internalization.

• 出版日期2012-10