Does the patients with cervical infection and symptoms of imminent preterm delivery has elevated serum levels of interferon gamma (IFN-gamma)

作者：Bogavac Mirjana^*; Brkic Snezana; Celic Dejan; Novakov Mikic Aleksandra; Ilic Tatjana; Eric Zelimir

来源：Healthmed, 2011, 5(6): 2196-2200.

• cytokines
• interferon gamma
• preterm delivery
• bacterial infection
• Candida
• Chlamydia trachomatis

Preterm delivery (PTD), defined as delivery prior to 37 completed weeks, increases risks of neonatal morbidity and mortality There is a growing body of evidence that intrauterine infection, as well as cervicovaginal bacterial infections and chlamydial infection are possible cause of preterm delivery((13,14)). Host response to cervicovaginal and/or intrauterine infections is a release of various inflammatory mediators, many of which are cytokines.
Aim of the study: To find out if cervical infection influence the level of serum interferon-gamma in patients with clinical symptoms of imminent preterm delivery.
Methods: 78 pregnant women (from 24 to 30 weeks of gestation) with clinical simptoms of imminent preterm delivery were divided in: study group - patients with cervical infection and control group - patients without cervical infection. The level of proinflammatory interferon-gamma in the serum was measured by ELISA test.
Results: There wasn't statistically significant difference in serum level of interferon-gamma between two investigated groups. (p=0.576)
Conclusions: The physiologic interferon-gamma levels in circulation during pregnancy is irrespective of the presence of cervicovaginal infections.

• 出版日期2011