APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese

作者：Chien Kuo Liong; Fang Woei Horng; Wen Hui Chin; Lin Hsing Pei; Lin Yen Lin; Lin Shu Wha; Wu June Hsieh; Kao Jau Tsuen^*

来源：Clinica Chimica Acta, 2008, 390(1-2): 56-62.

DOI：10.1016/j.cca.2007.12.014

• apolipoprotein A1/C3/A5
• triglyceride
• HDL cholesterol
• haplotype

Background: Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations. We investigated 2 distinct APOA1/C3/A5 haplotypes roles for hypertriglyceridemia.
Methods: We recruited 308 cases of hypertriglyceridemia and 281 normal controls from a hospital. Twelve single nucleotide polymorphisms (SNPs) across the APOA1/C3/A5 gene region were genotyped.
Results: One haplotype containing the minor alleles of the APOA5 (-1131T>C, c.553G>T) and APOA1 (-3013C>T,-75G>A) was more prevalent in cases than in controls (11.3% vs. 1.1%, respectively) and was statistically significantly associated with high triglycerides (adjusted odds ratio: 12.83, 95% confidence interval [CI]: 5.1-32.4, P<0.001). Another haplotype that was associated with hypertriglyceridemia (adjusted odds ratio 2.13, 95% CI, 1.37-3.29, P=0.001). Participants carrying both minor alleles of APOA5-1131CC and c.553TT had a 116% higher triglyceride concentration compared with those carrying common allele.
Conclusions: The APOA1/C3/A5 haplotype represents an important locus for predicting risk of hypertriglyceridemia among Taiwanese.

• 出版日期2008-4
• 单位长春大学