Adhesion of Preosteoblasts and Fibroblasts onto Poly(pentafluorostyrene)-Based Glycopolymeric Films and their Biocompatibility

作者：Babiuch Krzysztof; Becer C Remzi; Gottschaldt Michael; Delaney Joseph T; Weisser Juergen; Beer Birgitt; Wyrwa Ralf; Schnabelrauch Matthias; Schubert Ulrich S^*

来源：Macromolecular Bioscience, 2011, 11(4): 535-548.

DOI：10.1002/mabi.201000374

• adhesion
• click reaction
• coatings
• functionalization of polymers
• glycopolymer

An efficient and metal-catalyst free method of glycopolymer synthesis via thiol/para-fluorine "click'' reaction was used to graft acetylated 1-thio-beta-D-glucopyranose and 1-thio-beta-D-galactopyranose onto a homopolymer of pentafluorostyrene (PFS) as well as onto a block copolymer of styrene and PFS. Subsequent deprotection of the carbohydrate moieties yielded well-defined, sugar-modified polymers (PDI < 1.2). The prepared polymers were not cytotoxic against 3T3 fibroblasts and MC3T3-E1 preosteoblasts. Furthermore, the water-insoluble copolymers were drop-cast and examined as synthetic biocompatible coatings on poly(propylene) substrates for culturing the investigated cell types. Both fibro- and preosteoblasts showed stable adhesion and proliferation on the glycopolymer-coated surfaces.

• 出版日期2011-4-8