Achievement of complete molecular responses in late chronic phase chronic myeloid leukaemia patients treated with pulsed imatinib while in minimal residual disease

作者：Breccia Massimo^*; Cannella Laura; Stefanizzi Caterina; Santopietro Michelina; De Cuia Rosa; Diverio Daniela; Alimena Giuliana

来源：Leukemia Research, 2009, 33(5): 645-648.

DOI：10.1016/j.leukres.2008.10.024

• Chronic myeloid leukaemia
• Alpha-IFN
• Imatinib
• Complete cytogenetic remission
• Molecular response

Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400 mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late CP, which were switched to imatinib while in CCR after interferon alpha (IFN alpha) and reached complete and stable molecular remission with intermittent drug administration at 400 mg/every 20 days/month.

• 出版日期2009-5