Age-Dependent Sensitization to the 7S-Vicilin-Like Protein Cor a 11 From Hazelnut (Corylus avellana) in a Birch-Endemic Region

作者：Verweij M M; Hagendorens M M; Trashin S; Cucu T; De Meulenaer B; Devreese B; Bridts C H; De Clerck L S; Ebo D G^*

来源：Journal of Investigational Allergology and Clinical Immunology, 2012, 22(4): 245-251.

• Basophil activation
• Birch
• Cor a 11
• Component-resolved diagnosis
• Hazelnut
• IgE

Background: Hazelnut (Corylus avellana)allergy exhibits age and geographically distinct sensitization patterns that have not yet been fully resolved. %26lt;br%26gt;Objective: To study sensitization to Cor a 11 in different age groups of hazelnut-allergic patients and infants with atopic dermatitis (AD) sensitized to hazelnut in a birch-endemic region. %26lt;br%26gt;Methods: Sera from 80 hazelnut-allergic patients, 33 infants under 1 year of age with AD (24 sensitized and 9 not sensitized to hazelnut), 32 healthy control individuals, and 29 birch pollen allergic but hazelnut-tolerant individuals were tested for immunoglobulin (Ig) E reactivity to Cor a 11 by ImmunoCAP. IgE reactivity to Cor a 1.01, Cor a 1.04, Cor a 8, and Cor a 9 was studied by ISAC microarray. %26lt;br%26gt;Results: Forty patients (22 preschool children, 10 schoolchildren, and 8 adults) with systemic reactions on consumption of hazelnut were sensitized to Cor a 11 (respective rates of 36%, 40%, and 12.5%). Forty patients (6 preschool children, 10 schoolchildren, and 24 adults) reported oral allergy syndrome but only 2 of them (of preschool age) were sensitized to Cor a 11. Two (8%) of the AD infants sensitized to hazelnut showed IgE reactivity to Cor a 11. This reactivity was not observed in any of the AD infants without sensitization to hazelnut, in any of the birch-pollen allergic patients without hazelnut allergy, or in any of the healthy control individuals. %26lt;br%26gt;Conclusion: Sensitization to Cor a 11 in a birch-endemic region is predominantly found in children with severe hazelnut allergy, a finding that is consistent with observations concerning sensitization to Cor a 9.

• 出版日期2012