Differential interictal activity of the precuneus/posterior cingulate cortex revealed by resting state functional MRI at 3T in generalized vs. partial seizure

作者：Lui, Su; Ouyang, Luo; Chen, Qin; Huang, Xiaoqi; Tang, Hehan; Chen, Huafu; Zhou, Dong; Kemp, Graham J.; Gong, Qiyong^*

来源：Journal of Magnetic Resonance Imaging, 2008, 27(6): 1214-1220.

DOI：10.1002/jmri.21370

• fMRI
• interictal
• brain function
• epilepsy
• resting state

Purpose: To characterize, using functional MRI (fMRI), the pattern of active brain regions in the resting state in patients with epilepsy. @@@ Materials and Methods: We studied 28 patients with epilepsy, divided into a partial seizure (PS; N = 9) and a generalized seizure group (GS; N = 19), and 34 control subjects. Resting state, fMRI was performed using a GE 3T scanner by collecting 200 volumes of echo-planar imaging [EPI) images with subjects relaxed, eyes closed. Data were processed using a modification of the method of Fransson (Hum Brain Mapp 2005;26:15-29), which reveals information on regional low-frequency Blood Oxygenation Level Dependent (BOLD) signal oscillations In the resting state without any a priori hypothesis. The significant active areas in brain were identified with both individual and group analysis. @@@ Results:Controls showed active regions in the precuneus/posterior cingulate cortex (PCC) and media] prefrontal cortex (MPFC)/ventral anterior cingulate cortex (vACC), there-gions associated with the brain "default mode." Similar active regions were observed in PS, whereas GS showed no significant activation of precuneus/PCC. @@@ Conclusion: In GS, the lack of activation in precuneus/ PCC may partly account for their more severe interictal deficits, compared to PS, in cognitive functions such as concentration and memory.

• 出版日期2008-6
• 单位电子科技大学; 四川大学