Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment

作者：Chen, Sheng; Luo, Jinqi; Reis, Cesar; Manaenko, Anatol; Zhang, Jianmin^*

来源：Biomed Research International, 2017, 2017: 8584753.

DOI：10.1155/2017/8584753

• RUPTURED INTRACRANIAL ANEURYSMS
• LAMINA TERMINALIS FENESTRATION
• SHUNT-DEPENDENT HYDROCEPHALUS
• NORMAL-PRESSURE HYDROCEPHALUS
• RAT MODEL
• INTRAVENTRICULAR HEMORRHAGE
• DIFFUSION TENSOR
• RISK-FACTORS
• PREDICTORS
• IRON

Hydrocephalus (HCP) is a common complication in patients with subarachnoid hemorrhage. In this review, we summarize the advanced research on HCP and discuss the understanding of the molecular originators of HCP and the development of diagnoses and remedies ofHCP after SAH. It has been reported that inflammation, apoptosis, autophagy, and oxidative stress are the important causes of HCP, and well-known molecules including transforming growth factor, matrix metalloproteinases, and iron terminally lead to fibrosis and blockage ofHCP. Potentialmedicines forHCP are still in preclinical status, and surgery is the most prevalent and efficient therapy, despite respective risks of different surgicalmethods, including lamina terminalis fenestration, ventricle-peritoneal shunting, and lumbar-peritoneal shunting. HCP remains an ailment that cannot be ignored and even with various solutions the medical community is still trying to understand and settle why and how it develops and accordingly improve the prognosis of these patients with HCP.

• 出版日期2017
• 单位浙江大学