AN APPROACH TO THE SYNTHESIS OF NOVEL DIHYDROINDOLES BEARING ELECTRON-WITHDRAWING GROUPS AT C-2 POSITION

作者：Okabe Fumi^*; Maruoka Hiroshi; Takasu Masaru; Masumoto Eiichi; Fujioka Toshihiro; Yamagata Kenji

来源：Heterocycles, 2014, 88(1): 675-687.

DOI：10.3987/COM-13-S(S)21

• Furan
• Diels-Alder Reaction
• Indoline
• Diazo Compound
• Insertion Reaction

The synthesis of novel dihydroindoles 8a-d and 9a-d bearing electron-withdrawing groups at C-2 position is presented. The key step of this approach is an efficient intramolecular Diels-Alder reaction of N-alkenylated 2-amino-3-furancarbonitriles 4a-d and 5a-d.

• 出版日期2014-1-1