Antibacterial activity of pH-sensitive genipin cross-linked chitosan/poly(ethylene glycol)/silver nanocomposites

作者：Liu Yangshuo; Chen Wenbao; Kim Hyung Il^*

来源：Polymers for Advanced Technologies, 2012, 23(1): 8-14.

DOI：10.1002/pat.1818

• chitosan
• poly(ethylene glycol)
• silver
• antimicrobial activity
• nanocomposite

Novel nanocomposites consisting of genipin cross-linked chitosan (GC), poly(ethylene glycol) (PEG), and silver nanoparticles were prepared for such biomedical applications as the wound-healing materials. Various amounts of silver nanoparticles were dispersed in the GC/PEG hydrogel matrix without severe aggregation. The effects of composition and silver nanoparticles on the physico-chemical properties of samples were evaluated by infrared analysis, contact angle measurements, and swelling tests. The GC/PEG/Ag nanocomposite showed a pH-sensitive swelling behavior. The surface hydrophilicity of GC/PEG/Ag nanocomposites was improved with the increase of silver nanoparticle content. L929 cell attachment was improved in the presence of silver nanoparticles. The antimicrobial function was assessed for the GC/PEG/Ag nanocomposites containing the silver content over 100ppm. The silver nanoparticles had the dual functions of reinforcing structural stability and enhancing antimicrobial activity of GC/PEG/Ag nanocomposites.

• 出版日期2012-1