科研之友
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摘要
Background: Acute rejection (AR) and acute tubular necrosis (ATN) are main causes of early renal allograft dysfunction. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) and Diffusion weighted (DW) MRI can provide valuable information about changes of oxygen bioavailability and water diffusion by measuring R2* or apparent diffusion coefficient (ADC) respectively. We aimed to determine the value of BOLD MRI and DW MRI in detecting causes for early allograft dysfunction in renal allograft recipients. @@@ Methods: Fifty patients received renal allografts from deceased donors were analyzed, including 35 patients with normal renal control group), 10 AR patients and 5 ATN patients. Cortical R2* (CR2*) and medullary R2* (MR2*) were measured by BOLD MRI. Ten diffusion gradient b values (0, 5, 10, 20, 50, 100, 200, 400, 800, 1200s/mm(2)) were used in DW MRI. ADC values were measured in renal cortex (CADC) and medulla (MADC). CADC(l) and MADC(l) were measured under low b values (b <= 200 s/mm(2)), while CADC(h) and MADC(h) were measured under high b values (b > 200 s/mm(2)). @@@ Results: MR2* was significantly lower in AR group (18.2 +/- 1.5/s) than control group (23.8 +/- 5.0/s, p = 0.001) and ATN group (25.8 +/- 5.0/s, p = 0.004). There was a tendency of lower levels on CADC(l), MADC(l,) CADC(h) or MADC(h) in AR group than in control group. There were no differences on ADC values between AR group and ATN group. @@@ Conclusions: BOLD MRI was a valuable method in detection of renal allografts with acute rejection.
