An unusual clandestine laboratory synthesis of 3,4-methylenedioxyamphetamine (MDA)

作者：Dal Cason Terry A^*; Corbett Charlotte A; Poole Peter K; de Haseth James A; Gouldthorpe David K

来源：Forensic Science International, 2012, 223(1-3): 279-291.

DOI：10.1016/j.forsciint.2012.10.002

• 2-Chloro-4,5-methylenedioxyamphetamine
• alpha-Methyl-3,4-methylenedioxyphenylpropionamide
• Hofmann Degradation
• Hofmann Rearrangement
• 3,4-Methylenedioxyamphetamine
• Clandestine laboratory
• MDA
• MMDPPA

An unknown compound from a putative clandestine laboratory was analyzed by GC-MS, GC-IRD, IR (ATR), and NMR and found to be alpha-methyl-3,4-methylenedioxyphenylpropionamide (MMDPPA), an unusual precursor for the synthesis of 3,4-methylenedioxyamphetamine (MDA), a Schedule I controlled substance. A portion of this precursor was subjected to the Hofmann Degradation (i.e., Hofmann Rearrangement) reaction using a sodium hypochlorite solution (bleach) to produce the expected compound, MDA. When excess hypochlorite was used in the reaction, a second, unexpected, compound was formed. Use of the listed instrumentation identified the new material as 2-chloro-4,5-methylenedioxyamphetamine, a compound not previously identified in the forensic literature.

• 出版日期2012-11-30