Anti-cytokine therapies in T1D: Concepts and strategies

作者：Nepom Gerald T^*; Ehlers Mario; Mandrup Poulsen Thomas

来源：Clinical Immunology, 2013, 149(3): 279-285.

DOI：10.1016/j.clim.2013.02.003

• Immunotherapy
• Autoimmunity
• Regulatory T cells
• Anti-inflammatory

Therapeutic targeting of proinflammatory cytokines is clinically beneficial in several autoimmune disorders. Several of these cytokines are directly implicated in the pathogenesis of type 1 diabetes, suggesting opportunities for design of clinical trials in type 1 diabetes that incorporate selective cytokine blockade as a component of preventative or interventional immunotherapy. The rationale and status of inhibitory therapy directed against IL-1, TNF, IL-12, IL-23, and IL-6 are discussed, towards a goal of using cytokine inhibition as a therapeutic platform to establish an in vivo milieu suitable for modulating the immune response in T1D.

• 出版日期2013-12