Non-Random Mating Involving Inheritance of Social Status

作者：Chung Myung Hoon^*; Kim Chul Koo

来源：Journal of Computational Biology, 2010, 17(5): 745-754.

DOI：10.1089/cmb.2008.0152

• computer simulation
• non-random mating
• population evolution
• social gene

We propose a unified theoretical scheme to calculate genotype frequencies of polymorphic populations with biological and social inheritance. This scheme is used to simulate the effects of social non-random mating on the population's evolution in the general situation of multiple biological gene loci and allele inheritance with natural selection and mutation. We study the case of hemophilia in several diverse situations when there exists non-random mating due to inheritance of social status. This study clearly shows that interaction between the social and the biological gene has significant impact on the population's evolution.

• 出版日期2010-5